The emergence of antibiotic-resistant pathogenic bacteria in recent decades leads us to an
urgent need for the development of new antibacterial agents. The species of the genus …

The natural fermentation of antibiotics, along with semi-synthetic and synthetic approaches,
is one of the most important methods for their production. The majority of the antibiotic …

Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a
vital role in antimycobacterial therapy. As the first sequenced genome of the genus …

As a part of our ongoing efforts towards finding novel antimycotic agents from marine
microflora of the Red Sea, vanillin, 5, 7-dimethoxy-4-p-methoxylphenylcoumarin and the …

Ever since the isolation of Amycolatopsis mediterranei in 1957, this strain has been the
focus of research worldwide. In the last 60 years or more, our understanding of the …

Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically
used antibiotics that are effective against tuberculosis, leprosy, and AIDS-related …

Rifamycin and its derivatives are natural products that belong to the class of antibiotic-active
polyketides and have significant therapeutic relevance within the therapy scheme of …

Rifamycins are mainstay agents in treatment of many widespread diseases, but how an
improved rifamycin producer can be created is still incompletely understood. Here, we …

Actinobacteria are gram-positive filamentous bacteria which contains some of the most
deadly human pathogens (Mycobacterium tuberculosis, M. leprae, Corynebacterium …

Amycolatopsis mediterranei S699 is an actinomycete that produces an important antibiotic,
rifamycin B. Semisynthetic derivatives of rifamycin B are used for the treatment of …