Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

Microglia are brain-resident immune cells with a repertoire of functions in the brain.
However, the extent of their interactions with the vasculature and potential regulation of …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Alzheimer's disease (AD) remains one of the grand challenges facing human society. Much
controversy exists around the complex and multifaceted pathogenesis of this prevalent …