Our knowledge of the roles of individual cytochrome P450 (P450) enzymes in drug
metabolism has developed considerably in the past 30 years, and this base has been of …

Tachykinins (TKs) are ancient neuropeptides present throughout the bilaterians and are,
with some exceptions, characterized by a conserved FX1GX2Ramide carboxy terminus …

Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms
underlying these symptoms are unknown. We report that bile acids, which are elevated in …

A normal antibody-producing cell only expresses one antibody, resulting in the well-known
phenomenon of allelic exclusion. When two myeloma cells are fused, the derived hybrids …

BACKGROUND The determination of the presence or concentration of antigenic
substances, for example, those associated with a wide variety of physiological disorders, in …

The mammalian habenula is involved in regulating the activities of serotonergic and
dopaminergic neurons. It consists of the medial and lateral habenulae, with each subregion …

Regional loss of immunohistochemically identified neurons in serial sections through the
brainstem of 4 patients with idiopathic Parkinson's disease was compared with equivalent …

A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons,
defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence …

Two vesicular glutamate transporters, VGLUT1 and VGLUT2, have recently been identified,
and it has been reported that they are expressed by largely nonoverlap** populations of …

In Drosophila cells, regulatory mechanisms not only act to provide rapid induction of hsp70
during heat shock but also to prevent expression at normal temperatures. To determine …