Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising
source of new antimicrobials in the face of rising antibiotic resistance. Here, we report a …

Bacterial secondary metabolites are a major source of antibiotics and other bioactive
compounds. In microbial communities, these molecules can mediate interspecies …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural
product discovery by enabling the rapid investigation of secondary metabolic potential within …

Background Genome mining for biosynthetic gene clusters (BGCs) has become an integral
part of natural product discovery. The> 200,000 microbial genomes now publicly available …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …

Darobactin is a heptapeptide antibiotic featuring an ether cross-link and a C–C cross-link,
and both cross-links are installed by a radical S-adenosylmethionine (rSAM) enzyme DarE …

Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …