Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

To explore the human T cell response to acute viral infection, we performed a longitudinal
analysis of CD8+ T cells responding to the live yellow fever virus and smallpox vaccines …

Cellular immune responses play a critical role in the control of human immunodeficiency
virus type 1 (HIV-1); however, the breadth of these responses at the single-epitope level has …

The cytotoxic T-cell response in chronic hepatitis B virus (HBV) infection has been described
as weak and mono-or oligospecific in comparison to the more robust virus-specific T-cell …

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

Globally, over 500 million people are chronically infected with the hepatitis B virus (HBV) or
hepatitis C virus (HCV). These chronic infections cause liver inflammation, and may result in …

The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent
infection in more than two-thirds of those who contract it. Its success is related to its abilities …

Hepatitis C virus (HCV) infection frequently persists despite substantial virus-specific cellular
immune responses. To determine if immunologically driven sequence variation occurs with …

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T
lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …