Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …
mRNA cap**: biological functions and applications
The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …
of research have established that the m7G cap serves as a unique molecular module that …
Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …
and steady expression of some proteins as well as the rapidly changing production of other …
[HTML][HTML] Structural insights into RNA synthesis by the influenza virus transcription-replication machine
A Pflug, M Lukarska, P Resa-Infante, S Reich… - Virus research, 2017 - Elsevier
Influenza virus is a segmented, negative strand RNA virus with each genome segment being
packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the …
packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the …
The cap-snatching mechanism of bunyaviruses
In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain
heterologous sequences at their 5′ termini originating from capped host cell RNAs. These …
heterologous sequences at their 5′ termini originating from capped host cell RNAs. These …
The influenza virus polymerase complex: an update on its structure, functions, and significance for antiviral drug design
A Stevaert, L Naesens - Medicinal research reviews, 2016 - Wiley Online Library
Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …
Insight into influenza: a virus cap-snatching
C De Vlugt, D Sikora, M Pelchat - Viruses, 2018 - mdpi.com
The influenza A virus (IAV) genome consists of eight single-stranded RNA segments. Each
segment is associated with a protein complex, with the 3′ and 5′ ends bound to the RNA …
segment is associated with a protein complex, with the 3′ and 5′ ends bound to the RNA …
Role of MAPK/MNK1 signaling in virus replication
Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …
to effectively replicate and produce new progeny virus particles. Following viral infection …
Inhibition of cellular RNA methyltransferase abrogates influenza virus cap** and replication
Orthomyxo-and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own
transcription in a process called “cap snatching.” We report that RNA modification of the cap …
transcription in a process called “cap snatching.” We report that RNA modification of the cap …
Structural basis of an essential interaction between influenza polymerase and Pol II CTD
M Lukarska, G Fournier, A Pflug, P Resa-Infante… - Nature, 2017 - nature.com
The heterotrimeric influenza polymerase (FluPol), comprising subunits PA, PB1 and PB2,
binds to the conserved 5′ and 3′ termini (the 'promoter') of each of the eight single …
binds to the conserved 5′ and 3′ termini (the 'promoter') of each of the eight single …