Recent growth in annual new therapeutic entity (NTE) approvals by the US Food and Drug
Administration (FDA) suggests a positive trend in current research and development (R&D) …

A cross‐industry survey was conducted to assess the landscape of preclinical quantitative
systems pharmacology (QSP) modeling within pharmaceutical companies. This article …

Mechanistic physiological modeling is a scientific method that combines available data with
scientific knowledge and engineering approaches to facilitate better understanding of …

Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and
disease modeling, seeks to address a diverse set of problems in the discovery and …

Quantitative and systems pharmacology concepts and tools are the foundation of the model‐
informed drug development paradigm at Merck for integrating knowledge, enabling …

Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing
promising results for the treatment of numerous cancers refractory to conventional therapies …

BioModels is a reference repository hosting mathematical models that describe the dynamic
interactions of biological components at various scales. The resource provides access to …

Identifying ligands targeting G protein coupled receptors (GPCRs) with novel chemotypes
other than the physiological ligands is a challenge for in silico screening campaigns. Here …

Immuno‐oncology (IO) is a fast‐expanding field due to recent success using IO therapies in
treating cancer. As IO therapies do not directly kill tumor cells but rather act upon the …

Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder with
heterogeneous clinical manifestations, including hepatosplenomegaly and infiltrative …