In the last decade, burst suppression has been increasingly studied by many to examine
whether it is a mechanism leading to postoperative cognitive impairment. Despite a lack of …

Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful
tools to study brain development and dysfunction. However, whether organoids can …

The central and peripheral nervous systems are the primary target organs during
anaesthesia. At the time of the inception of the British Journal of Anaesthesia, monitoring of …

Purpose Anesthesiologists simultaneously manage several aspects of patient care during
general anesthesia. Automating administration of hypnotic agents could enable more …

Unconsciousness maintained by GABAergic anesthetics, such as propofol and sevoflurane,
is characterized by slow-delta oscillations (0.3 to 4 Hz) and alpha oscillations (8 to 14 Hz) …

William Morton introduced the world to ether anesthesia for use during surgery in the
Bullfinch Building of the Massachusetts General Hospital on October 16, 1846. For nearly …

In develo** rats, behavioral state exerts a profound modulatory influence on neural activity
throughout the sensorimotor system, including primary motor cortex (M1). We hypothesized …

Background During clinical anaesthesia, the administration of analgesics mostly relies on
empirical knowledge and observation of the patient's reactions to noxious stimuli. Previous …

The most common complication in older surgical patients is postoperative delirium (POD).
POD is associated with preoperative cognitive impairment and longer durations of …

Background: Burst suppression (BS) is an electroencephalography (EEG) pattern in which
there are isoelectric periods interspersed with bursts of cortical activity. Targeting BS through …