Label-free microfluidic cell sorting and detection for rapid blood analysis

N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …

Mechanical adaptability of tumor cells in metastasis

V Gensbittel, M Kräter, S Harlepp, I Busnelli, J Guck… - Developmental cell, 2021 - cell.com
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Microfluidic technologies for cell deformability cytometry

H Chen, J Guo, F Bian, Y Zhao - Smart Medicine, 2022 - Wiley Online Library
Microfluidic detection methods for cell deformability cytometry have been regarded as
powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been …

Nonlinear microfluidics

D Stoecklein, D Di Carlo - Analytical chemistry, 2018 - ACS Publications
Microfluidic flow is commonly employed in the biological, chemical, or physical analysis of
samples in small fluid volumes because of the typical lack of nonlinear phenomena, with …

Microfluidic and nanofluidic intracellular delivery

J Hur, AJ Chung - Advanced Science, 2021 - Wiley Online Library
Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

Microfluidic impedance‐deformability cytometry for label‐free single neutrophil mechanophenoty**

C Petchakup, H Yang, L Gong, L He, HM Tay, R Dalan… - Small, 2022 - Wiley Online Library
The intrinsic biophysical states of neutrophils are associated with immune dysfunctions in
diseases. While advanced image‐based biophysical flow cytometers can probe cell …

Cells under stress: an inertial-shear microfluidic determination of cell behavior

FJ Armistead, JG De Pablo, H Gadêlha, SA Peyman… - Biophysical journal, 2019 - cell.com
The deformability of a cell is the direct result of a complex interplay between the different
constituent elements at the subcellular level, coupling a wide range of mechanical …

Hydrodynamics in cell studies

D Huber, A Oskooei, X Casadevall i Solvas… - Chemical …, 2018 - ACS Publications
Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

Characterizing deformability and electrical impedance of cancer cells in a microfluidic device

Y Zhou, D Yang, Y Zhou, BL Khoo, J Han… - Analytical …, 2018 - ACS Publications
Mechanical properties of cells, reflective of various biochemical characteristics such as gene
expression and cytoskeleton, are promising label-free biomarkers for studying and …

Biomechanical properties of cancer cells

G Runel, N Lopez-Ramirez, J Chlasta, I Masse - Cells, 2021 - mdpi.com
Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …