Digital solutions in paediatric sepsis: current state, challenges, and opportunities to improve care around the world

LN Sanchez-Pinto, MPA López, H Scott… - The Lancet Digital …, 2024 - thelancet.com
The digitisation of health care is offering the promise of transforming the management of
paediatric sepsis, which is a major source of morbidity and mortality in children worldwide …

An Atlas of Variant Effects to understand the genome at nucleotide resolution

DM Fowler, DJ Adams, AL Gloyn, WC Hahn, DS Marks… - Genome Biology, 2023 - Springer
Sequencing has revealed hundreds of millions of human genetic variants, and continued
efforts will only add to this variant avalanche. Insufficient information exists to interpret the …

Improving natural product research translation: From source to clinical trial

BC Sorkin, AJ Kuszak, G Bloss… - The FASEB …, 2020 - Wiley Online Library
While great interest in health effects of natural product (NP) including dietary supplements
and foods persists, promising preclinical NP research is not consistently translating into …

Cactaceae at Caryophyllales. org–a dynamic online species-level taxonomic backbone for the family

N Korotkova, D Aquino, S Arias, U Eggli, A Franck… - Willdenowia, 2021 - BioOne
This data paper presents a largely phylogeny-based online taxonomic backbone for the
Cactaceae compiled from literature and online sources using the tools of the EDIT Platform …

[HTML][HTML] Monetisation of digital health data through a GDPR-compliant and blockchain enabled digital health data marketplace: A proposal to enhance patient's …

M Maher, I Khan, V Prikshat - International Journal of Information …, 2023 - Elsevier
With the growing use of digital technologies, the vision of a predictive, preventive and
personalised healthcare system, commonly termed healthcare 4.0, is becoming tangible …

The evolution of Materials Acceleration Platforms: toward the laboratory of the future with AMANDA

J Wagner, CG Berger, X Du, T Stubhan… - Journal of Materials …, 2021 - Springer
The development of complex functional materials poses a multi-objective optimization
problem in a large multi-dimensional parameter space. Solving it requires reproducible, user …

Sharing brain imaging data in the Open Science era: how and why?

K Giehl, HJ Mutsaerts, K Aarts, F Barkhof… - The Lancet Digital …, 2024 - thelancet.com
The sharing of human neuroimaging data has great potential to accelerate the development
of imaging biomarkers in neurological and psychiatric disorders; however, major obstacles …

Images are data: challenges and opportunities in the clinical translation of radiomics

W Mu, MB Schabath, RJ Gillies - Cancer Research, 2022 - AACR
Radiomics provides an opportunity to uncover image-based biomarkers through the
conversion and analysis of standard-of-care medical images into high-dimensional …

Reinventing radiation therapy with machine learning and imaging bio-markers (radiomics): State-of-the-art, challenges and perspectives

L Dercle, T Henry, A Carré, N Paragios, E Deutsch… - Methods, 2021 - Elsevier
Radiation therapy is a pivotal cancer treatment that has significantly progressed over the last
decade due to numerous technological breakthroughs. Imaging is now playing a critical role …

Explainable biology for improved therapies in precision medicine: AI is not enough

I Jurisica - Best Practice & Research Clinical Rheumatology, 2024 - Elsevier
Technological advances and high-throughput bio-chemical assays are rapidly changing
ways how we formulate and test biological hypotheses, and how we treat patients. Most …