Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and
cardiovascular disease. In the past decade, a large number of endocrine, inflammatory …

The discovery of the genetic basis for circadian rhythms has expanded our knowledge of the
temporal organization of behavior and physiology. The observations that the circadian gene …

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid
(BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and …

Carnitine is a conditionally essential nutrient that plays a vital role in energy production and
fatty acid metabolism. Vegetarians possess a greater bioavailability than meat eaters …

Thyroid hormones have widespread cellular effects; however it is unclear whether their
effects on the central nervous system (CNS) contribute to global energy balance. Here we …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Adipocytes store excess energy in the form of triglycerides and signal the levels of stored
energy to the brain. Here we show that adipocyte-specific deletion of Arntl (also known as …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Current evidence suggests that hypothalamic fatty acid metabolism may play a role in
regulating food intake; however, confirmation that it is a physiologically relevant regulatory …

Thyroid disease and type 1 but also type 2 diabetes mellitus (DM) are strongly associated,
and this has important clinical implications for insulin sensitivity and treatment requirements …