Hypospadias results from a failure of urethral closure in the male phallus and affects 1 in
200-300 boys. It is thought to be due to a combination of genetic and environmental factors …

BACKGROUND Hypospadias is a common congenital malformation of the male external
genitalia. Most cases have an unknown aetiology, which is probably a mix of monogenic …

Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

Cryptorchidism is the most frequent congenital birth defect in male children (2–4% in full-
term male births), and it has the potential to impact the health of the human male. In fact …

Male factor accounts for about 30–50% of infertility. A common cause of male infertility is
drug abuse; either illicit or prolonged use of prescribed drugs. This study provides a review …

Background The assisted reproductive techniques aimed to assist infertile couples have
their own offspring carry significant risks of passing on molecular defects to next …

BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …

Despite significant advances in contraceptive options for women over the last 50 yr, world
population continues to grow rapidly. Scientists and activists alike point to the devastating …

In recent years, evidences have accumulated that exposure to environmental components
with estrogenic activity causes reproductive disorders in human populations. Studies …

Despite the identification of an increasing number of candidate genes involved in
spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains …