Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and
phthalazines are important structural feature of many biologically active compounds and …

Perceiving a pharmacophore is the first essential step towards understanding the interaction
between a receptor and a ligand. Once a pharmacophore is established, a beneficial use of …

With computer-aided drug design established as an integral part of the lead discovery and
optimization process, pharmacophores have become a focal point for conceptualizing and …

Pharmacophore hypotheses were developed for a series of 2, 4-diamino-5-deazapteridine
inhibitors of Mycobacterium avium complex (MAC) and human dihydrofolate reductase …

Reactions of the Schiff base ligand derived from 4-acetyl-5, 6-diphenyl-3 (2H)-pyridazinone
and ethylenediamine with Ni (II) and Co (II) using different metal salts; NO 3−, AcO−, ClO 4 …

Pyridazinones have drawn a substantial attention within the field of research analysis and
development. The moiety is a subject matter of intensive research because of its wide …

The use of the internet has evolved in quantitative structure–activity relationship (QSAR)
over the past decade with the development of web based activities like the availability of …

Hypertension is one of the most serious health problems of the modern world with a
continuous rise in the number of patients. Selective α1-adrenoreceptor antagonists though …

A new Schiff base ligand was synthesized by the reaction of 4-acetyl-5, 6-diphenyl-3 (2H)-
pyridazinone with ethylenediamine. A series of binary copper (II) Schiff base complexes …

In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …