Causes and consequences of snake venom variation
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …
species. This variability has serious consequences for the management of the world's 1.8 …
The rise of genomics in snake venom research: recent advances and future perspectives
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
Microchromosomes are building blocks of bird, reptile, and mammal chromosomes
Microchromosomes, once considered unimportant shreds of the chicken genome, are gene-
rich elements with a high GC content and few transposable elements. Their origin has been …
rich elements with a high GC content and few transposable elements. Their origin has been …
Functional genomic diversity is correlated with neutral genomic diversity in populations of an endangered rattlesnake
Theory predicts that genetic erosion in small, isolated populations of endangered species
can be assessed using estimates of neutral genetic variation, yet this widely used approach …
can be assessed using estimates of neutral genetic variation, yet this widely used approach …
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
K Suryamohan, SP Krishnankutty, J Guillory, M Jevit… - Nature Genetics, 2020 - nature.com
Snakebite envenoming is a serious and neglected tropical disease that kills~ 100,000
people annually. High-quality, genome-enabled comprehensive characterization of toxin …
people annually. High-quality, genome-enabled comprehensive characterization of toxin …
Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features
In some mammals, notably humans, recombination occurs almost exclusively where the
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …
Phylogenetically diverse diets favor more complex venoms in North American pitvipers
The role of natural selection in the evolution of trait complexity can be characterized by
testing hypothesized links between complex forms and their functions across species …
testing hypothesized links between complex forms and their functions across species …
Sex chromosome evolution among amniotes: is the origin of sex chromosomes non-random?
Sex chromosomes are a great example of a convergent evolution at the genomic level,
having evolved dozens of times just within amniotes. An intriguing question is whether this …
having evolved dozens of times just within amniotes. An intriguing question is whether this …
Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …
The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such
variation, especially for complex traits, is challenging. Snake venoms provide a model …
variation, especially for complex traits, is challenging. Snake venoms provide a model …