Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

Lung cancer is the most common and aggressive tumor in the world. Long non-coding RNA
small nucleolar RNA host gene 1 (lncRNA SNHG1) play critical roles in the progression of …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Increased cancer stem cell content during development of resistance to tamoxifen in breast
cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Embryonic genetic programs are reactivated in response to various types of tissue damage,
providing cell plasticity for tissue regeneration or disease progression. In acute conditions …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors
while current therapeutic approaches show little effect of prolonging the survival of patients …