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CFD-PK model for nasal suspension sprays: Validation with human adult in vivo data for triamcinolone acetonide
The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
Anatomically-detailed segmented representative adult and pediatric nasal models for assessing regional drug delivery and bioequivalence with suspension nasal …
In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …
products. This study aims to evaluate the potential for using regional deposition …
Development of a predictive model for pediatric intranasal drug delivery with nasal sprays: Leveraging intersubject variability in anatomical dimensions, administration …
In this study, we examined the correlation between anatomical dimensions, spray
administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro …
administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro …
[PDF][PDF] Mechanistic Modeling and Realistic In Vitro Models to Facilitate Development of Generic Nasal Drug Products
R Walenga - 2022 - complexgenerics.org
–Low and high deposition models must differ by two standard deviations from the mean
value of posterior deposition for all 40 models. The medium model should be not …
value of posterior deposition for all 40 models. The medium model should be not …