Natural products: A lead for drug discovery and development

B Chopra, AK Dhingra - Phytotherapy Research, 2021 - Wiley Online Library
Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Piperine: A review of its biological effects

IU Haq, M Imran, M Nadeem, T Tufail… - Phytotherapy …, 2021 - Wiley Online Library
Medicinal plants have been used for years as a source of food, spices, and, in traditional
medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family …

Efflux pump inhibitors for bacterial pathogens: From bench to bedside

A Sharma, VK Gupta, R Pathania - Indian Journal of Medical …, 2019 - journals.lww.com
With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

[HTML][HTML] Development of botanicals to combat antibiotic resistance

PD Gupta, TJ Birdi - Journal of Ayurveda and integrative medicine, 2017 - Elsevier
The discovery of antibiotics in the previous century lead to reduction in mortality and
morbidity due to infectious diseases but their inappropriate and irrational use has resulted in …

[HTML][HTML] Piperine: A comprehensive review of methods of isolation, purification, and biological properties

A Tiwari, KR Mahadik, SY Gabhe - Medicine in Drug Discovery, 2020 - Elsevier
Black pepper is an autoicous and decorous vine cultivated and harvested in tropical regions
of Sri Lanka and India. Black pepper is one of the most commonly consumed spices, and its …

Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance

V Shriram, T Khare, R Bhagwat, R Shukla… - Frontiers in …, 2018 - frontiersin.org
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …

[HTML][HTML] Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism

KN Adams, K Takaki, LE Connolly, H Wiedenhoft… - Cell, 2011 - cell.com
Treatment of tuberculosis, a complex granulomatous disease, requires long-term multidrug
therapy to overcome tolerance, an epigenetic drug resistance that is widely attributed to …

[HTML][HTML] Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

AJ Seukep, V Kuete, L Nahar, SD Sarker… - Journal of pharmaceutical …, 2020 - Elsevier
The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …

Natural products as alternative choices for P-glycoprotein (P-gp) inhibition

S Dewanjee, T K. Dua, N Bhattacharjee, A Das… - Molecules, 2017 - mdpi.com
Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical
treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be …

New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria

MJ Nasiri, M Haeili, M Ghazi, H Goudarzi… - Frontiers in …, 2017 - frontiersin.org
Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …