Recent progress in the science of complex coacervation

CE Sing, SL Perry - Soft Matter, 2020 - pubs.rsc.org
Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

New frontiers for the materials genome initiative

JJ de Pablo, NE Jackson, MA Webb, LQ Chen… - npj Computational …, 2019 - nature.com
Abstract The Materials Genome Initiative (MGI) advanced a new paradigm for materials
discovery and design, namely that the pace of new materials deployment could be …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

Driving force and pathway in polyelectrolyte complex coacervation

S Chen, ZG Wang - … of the National Academy of Sciences, 2022 - National Acad Sciences
There is notable discrepancy between experiments and coarse-grained model studies
regarding the thermodynamic driving force in polyelectrolyte complex coacervation …

Polyelectrolyte complex coacervation across a broad range of charge densities

AE Neitzel, YN Fang, B Yu, AM Rumyantsev… - …, 2021 - ACS Publications
Polyelectrolyte complex coacervates of homologous (co) polyelectrolytes with a near-ideally
random distribution of a charged and neutral ethylene oxide comonomer were synthesized …

Dehydration entropy drives liquid-liquid phase separation by molecular crowding

S Park, R Barnes, Y Lin, B Jeon, S Najafi… - Communications …, 2020 - nature.com
Complex coacervation driven liquid-liquid phase separation (LLPS) of biopolymers has
been attracting attention as a novel phase in living cells. Studies of LLPS in this context are …

Unlocking the electrochemical functions of biomolecular condensates

Y Dai, ZG Wang, RN Zare - Nature Chemical Biology, 2024 - nature.com
Biomolecular condensation is a key mechanism for organizing cellular processes in a
spatiotemporal manner. The phase-transition nature of this process defines a density …

Biomolecular condensates regulate cellular electrochemical equilibria

Y Dai, Z Zhou, W Yu, Y Ma, K Kim, N Rivera… - Cell, 2024 - cell.com
Control of the electrochemical environment in living cells is typically attributed to ion
channels. Here, we show that the formation of biomolecular condensates can modulate the …

Formation of multiphase complex coacervates and partitioning of biomolecules within them

GA Mountain, CD Keating - Biomacromolecules, 2019 - ACS Publications
Biological systems employ liquid–liquid phase separation to localize macromolecules and
processes. The properties of intracellular condensates that allow for multiple, distinct liquid …

Liquid–liquid phase separation in artificial cells

CD Crowe, CD Keating - Interface Focus, 2018 - royalsocietypublishing.org
Liquid–liquid phase separation (LLPS) in biology is a recently appreciated means of
intracellular compartmentalization. Because the mechanisms driving phase separations are …