European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas

G Raverot, P Burman, A McCormack… - European journal of …, 2018 - academic.oup.com
Background Pituitary tumours are common and easily treated by surgery or medical
treatment in most cases. However, a small subset of pituitary tumours does not respond to …

Epidemiologic and molecular prognostic review of glioblastoma

JP Thakkar, TA Dolecek, C Horbinski, QT Ostrom… - … , biomarkers & prevention, 2014 - AACR
Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous
system malignancy with a median survival of 15 months. The average incidence rate of GBM …

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter …

U Herrlinger, T Tzaridis, F Mack, JP Steinbach… - The lancet, 2019 - thelancet.com
Background There is an urgent need for more effective therapies for glioblastoma. Data from
a previous unrandomised phase 2 trial suggested that lomustine-temozolomide plus …

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 …

M Weller, N Butowski, DD Tran, LD Recht, M Lim… - The lancet …, 2017 - thelancet.com
Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR
deletion mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole …

Bevacizumab plus radiotherapy–temozolomide for newly diagnosed glioblastoma

OL Chinot, W Wick, W Mason… - … England Journal of …, 2014 - Mass Medical Soc
Background Standard therapy for newly diagnosed glioblastoma is radiotherapy plus
temozolomide. In this phase 3 study, we evaluated the effect of the addition of bevacizumab …

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year …

R Stupp, ME Hegi, WP Mason, MJ Van Den Bent… - The lancet …, 2009 - thelancet.com
Background In 2004, a randomised phase III trial by the European Organisation for
Research and Treatment of Cancer (EORTC) and National Cancer Institute of Canada …

Primary brain tumours in adults

D Ricard, A Idbaih, F Ducray, M Lahutte… - The Lancet, 2012 - thelancet.com
Important advances have been made in the understanding and management of adult
gliomas and primary CNS lymphomas—the two most common primary brain tumours …

The many facets of therapy resistance and tumor recurrence in glioblastoma

A Goenka, D Tiek, X Song, T Huang, B Hu, SY Cheng - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …

Current concepts and management of glioblastoma

M Preusser, S De Ribaupierre, A Wöhrer… - Annals of …, 2011 - Wiley Online Library
Glioblastoma is the most common malignant primary brain tumor in adults. Its often rapid
clinical course, with many medical and psychosocial challenges, requires a multidisciplinary …

Glioblastoma multiforme: a review of where we have been and where we are going

C Adamson, OO Kanu, AI Mehta, C Di… - Expert opinion on …, 2009 - Taylor & Francis
Malignant gliomas such as glioblastoma multiforme (GBM) present some of the greatest
challenges in the management of cancer patients worldwide, despite notable recent …