Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pum** throughout the mammal's lifespan. This process is …

Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts
of infarcted myocardium and beat in synchrony with the heart, but in some settings cause …

Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

Cell-based therapies represent a very promising strategy to repair and regenerate the
injured heart to prevent progression to heart failure. To date, these therapies have had …

Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …

Some of the most significant leaps in the history of modern civilization—the development of
article in China, the steam engine, which led to the European industrial revolution, and the …

Myocyte death occurs in many inherited and acquired cardiomyopathies, including
arrhythmogenic cardiomyopathy (ACM), a genetic heart disease plagued by the prevalence …

The discovery of the first heart field (FHF) and the second heart field (SHF) led us to
understand how cardiac lineages and structures arise during development. However, it …

Functional cardiac tissue engineering holds promise as a candidate therapy for myocardial
infarction and heart failure. Generation of “strong-contracting and fast-conducting” cardiac …