Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with
hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted …

The Wnt signaling pathway is a highly conserved system that regulates complex biological
processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

Wnt signaling is a key regulator of vertebrate heart development; however, specific roles for
human cardiomyocyte development remain uncertain. Here we use human embryonic stem …

Aberrant activation of Wnt signaling is a crucial event in tumor development and metastasis.
Wnt signaling is commonly divided into canonical and non-canonical signaling pathways …

The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is
maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of …

Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell
proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a …

Ovarian cancer (OC) can be classified into five biologically distinct molecular subgroups:
epithelial-A (Epi-A), Epi-B, mesenchymal (Mes), Stem-A and Stem-B. Among them, Stem-A …

Frizzled (FZD) receptors mediate Wnt signaling in diverse processes ranging from bone
growth to stem cell activity. Moreover, high FZD receptor expression at the cell surface …

Increased protein translation in cells and various factors in the tumor microenvironment can
induce endoplasmic reticulum (ER) stress, which initiates the unfolded protein response …