Summary tRNA is the most extensively modified RNA in cells. On average, a bacterial tRNA
contains 8 modifications per molecule and a eukaryotic tRNA contains 13 modifications per …

Deazaguanine modifications play multifaceted roles in the molecular biology of DNA and
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …

The success of bacterial pathogens depends on the coordinated expression of virulence
determinants. Regulatory circuits that drive pathogenesis are complex, multilayered, and …

The microbiota plays essential roles in health and disease, in both the intestine and the
extra-intestine. Dysbiosis of the gut microbiota causes dysfunction in the intestine, which …

Queuosine (Q) is a complex tRNA modification found in bacteria and eukaryotes at position
34 of four tRNAs with a GUN anticodon, and it regulates the translational efficiency and …

Breast cancer (BC) is the most common cancer in women in the United States. There has
been an increasing incidence and decreasing mortality rate of BC cases over the past …

Transfer RNAs (tRNAs) play pivotal roles in the transmission of genetic information, and
abnormality of tRNAs directly leads to translation disorders and causes diseases, including …

Introduction A growing body of evidence indicates that the dysbiosis of both mammary and
intestinal microbiota is associated with the initiation and progression of breast tumors …

During infection, Salmonella hijacks essential host signaling pathways. These molecular
manipulations disrupt cellular integrity and may induce oncogenic transformation. Systemic …

Population diversity is one important characteristic of a microbiome community, which is
highly related to its environment. The change of diversity may indicate that an environment …