Discovery of microbial natural products by activation of silent biosynthetic gene clusters

PJ Rutledge, GL Challis - Nature reviews microbiology, 2015 - nature.com
Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Regulation of fungal secondary metabolism

AA Brakhage - Nature Reviews Microbiology, 2013 - nature.com
Fungi produce a multitude of low-molecular-mass compounds known as secondary
metabolites, which have roles in a range of cellular processes such as transcription …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Aspergillus flavus

S Amaike, NP Keller - Annual review of phytopathology, 2011 - annualreviews.org
Aspergillus flavus is saprophytic soil fungus that infects and contaminates preharvest and
postharvest seed crops with the carcinogenic secondary metabolite aflatoxin. The fungus is …

Fungal secondary metabolites–strategies to activate silent gene clusters

AA Brakhage, V Schroeckh - Fungal Genetics and Biology, 2011 - Elsevier
Filamentous fungi produce a multitude of low molecular weight bioactive compounds. The
increasing number of fungal genome sequences impressively demonstrated that their …

Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery

S Bertrand, N Bohni, S Schnee, O Schumpp… - Biotechnology …, 2014 - Elsevier
Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …

Regulation and role of fungal secondary metabolites

J Macheleidt, DJ Mattern, J Fischer… - Annual review of …, 2016 - annualreviews.org
Fungi have the capability to produce a tremendous number of so-called secondary
metabolites, which possess a multitude of functions, eg, communication signals during …

Strategies to diversify natural products for drug discovery

G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

T Netzker, J Fischer, J Weber, DJ Mattern… - Frontiers in …, 2015 - frontiersin.org
Microorganisms form diverse multispecies communities in various ecosystems. The high
abundance of fungal and bacterial species in these consortia results in specific …

Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel …

P Wiemann, CMK Sieber, KW Von Bargen… - PLoS …, 2013 - journals.plos.org
The fungus Fusarium fujikuroi causes “bakanae” disease of rice due to its ability to produce
gibberellins (GAs), but it is also known for producing harmful mycotoxins. However, the …