A strong cohort of evidence exists that supports the localisation of corneal stem cells at the
limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling …

Our window to the world is provided by the cornea on the front surface of the eye. The
integrity and functionality of the outermost corneal epithelium is essential for vision. A …

Human induced pluripotent stem cells (hiPSCs) offer unique opportunities for develo**
novel cell-based therapies and disease modeling. In this study, we developed a directed …

Limbal epithelial stem cell (LESC) deficiency (LSCD) leads to corneal abnormalities
resulting in compromised vision and blindness. LSCD can be potentially treated by …

In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these
studies involve invasive tissue sampling and toxic effects in animal models. Therefore …

Organ culture storage techniques for corneoscleral limbal (CSL) tissue have improved the
quality of corneas for transplantation and allow for longer storage times. Cultured limbal …

Stem cells have turned into promising tools for studying the mechanisms of development,
regeneration, and for cell therapy of various disorders. Stem cells are found in the embryo …

Immunologic graft rejection is the main complication after corneal transplant into
pathologically prevascularized so-called high-risk eyes. The aim of this study was to …

Limbal epithelial stem cells (LESCs) are a population of stem cells responsible for
maintenance and repair of the corneal surface. Injury and disease can result in a deficiency …

Corneal tissue regeneration is of crucial importance for maintaining normal vision. We
aimed to isolate and cultivate human corneal stroma-derived mesenchymal stem-like cells …