For a long time, cysteine cathepsins were considered primarily as proteases crucial for
nonspecific bulk proteolysis in the endolysosomal system. However, this view has …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

A proteoform is a defined form of a protein derived from a given gene with a specific amino
acid sequence and localized post‐translational modifications. In top‐down proteomic …

Cysteine protease cathepsins have traditionally been considered as lysosome-restricted
proteases that mediate proteolysis of unwanted proteins. However, studies from the past …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …

Cysteine cathepsins have been for a long time considered to execute mainly nonspecific
bulk proteolysis in the endolysosomal system. However, this view has been changing …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

Simple Summary Cancer, a major public health issue worldwide, is the second most
common cause of death. Initiatives such as the Human Genome Project (HGP) and Human …