A brief history and advancement of contraceptive multipurpose prevention technology (cMPT) products
The high incidence of HIV and other sexually transmitted infections (STIs), and an unmet
need for modern contraception resulting in a high unintended pregnancy rate, are major …
need for modern contraception resulting in a high unintended pregnancy rate, are major …
HIV-1 entry and prospects for protecting against infection
Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after
infection, which poses a major challenge for drug treatment and curative strategies. Many …
infection, which poses a major challenge for drug treatment and curative strategies. Many …
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
Given that HIV evolution and latent reservoir establishment occur continually within-host,
and that latently infected cells can persist long-term, the HIV reservoir should comprise a …
and that latently infected cells can persist long-term, the HIV reservoir should comprise a …
Existence of replication-competent minor variants with different coreceptor usage in plasma from HIV-1-infected individuals
Y Maeda, T Takemura, T Chikata, T Kuwata… - Journal of …, 2020 - Am Soc Microbiol
Cell entry by HIV-1 is mediated by its principal receptor, CD4, and a coreceptor, either CCR5
or CXCR4, with viral envelope glycoprotein gp120. Generally, CCR5-using HIV-1 variants …
or CXCR4, with viral envelope glycoprotein gp120. Generally, CCR5-using HIV-1 variants …
Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa
JL Baker, D Shriner, AR Bentley… - The pharmacogenomics …, 2017 - nature.com
As the common birthplace of all human populations, modern humans have lived longer on
the African continent than in any other geographical region of the world. This long history …
the African continent than in any other geographical region of the world. This long history …
Frequency of the CCR5-delta32 allele in Brazilian populations: A systematic literature review and meta-analysis
WHV Silva-Carvalho, RR de Moura… - Infection, Genetics and …, 2016 - Elsevier
The CCR5 is a chemokine receptor widely expressed by several immune cells that are
engaged in inflammatory responses. Some populations have individuals exhibiting a 32 bp …
engaged in inflammatory responses. Some populations have individuals exhibiting a 32 bp …
HIV-1 infection in persons homozygous for CCR5-Δ32 allele: the next case and the review
J Smoleń-Dzirba, M Rosińska, J Janiec… - AIDS …, 2017 - discovery.ucl.ac.uk
CC-chemokine receptor 5 serves as the coreceptor for the HIV-1 R5 strains, which are
responsible for the majority of HIV transmissions. A deletion of 32 nucleotides in the gene …
responsible for the majority of HIV transmissions. A deletion of 32 nucleotides in the gene …
Cell and gene therapy strategies to eradicate HIV reservoirs
C Spragg, HDS Feelixge… - Current Opinion in HIV and …, 2016 - journals.lww.com
Cell and gene therapy strategies to eradicate HIV reservoirs : Current Opinion in HIV and
AIDS Cell and gene therapy strategies to eradicate HIV reservoirs : Current Opinion in HIV …
AIDS Cell and gene therapy strategies to eradicate HIV reservoirs : Current Opinion in HIV …
Inferring the multiplicity of founder variants initiating HIV-1 infection: a systematic review and individual patient data meta-analysis
Background HIV-1 infections initiated by multiple founder variants are characterised by a
higher viral load and a worse clinical prognosis than those initiated with single founder …
higher viral load and a worse clinical prognosis than those initiated with single founder …
Deep sequencing increases hepatitis C virus phylogenetic cluster detection compared to Sanger sequencing
Effective surveillance and treatment strategies are required to control the hepatitis C virus
(HCV) epidemic. Phylogenetic analyses are powerful tools for reconstructing the …
(HCV) epidemic. Phylogenetic analyses are powerful tools for reconstructing the …