The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when
overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the …

This comprehensive review thoroughly explores the intricate involvement of insulin receptor
(IR) isoforms and insulin-like growth factor receptors (IGFRs) in the context of the insulin and …

It is now widely accepted that insulin resistance and compensatory hyperinsulinemia are
associated to increased cancer incidence and mortality. Moreover, cancer development and …

Discoidin domain receptors (DDRs) are one of the less explored targets for the treatment of
cancer which belong to receptor tyrosine kinases family. Discoidin domain receptors (DDRs) …

Purpose: Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and
progression and associated cancer phenotypes. We previously identified E-cadherin …

Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine
activities. Together with their receptors, binding proteins and associated molecules, they …

In the past few decades, the incidence of thyroid cancer (TC), namely of its papillary
hystotype (PTC), has shown a steady increase worldwide, which has been attributed at least …

Adipose tissue is the primary source of many pro-inflammatory cytokines in obesity.
Macrophage numbers and pro-inflammatory gene expression are positively associated with …

Discoidin Domain Receptor 1 (DDR1) is a collagen receptor tyrosine-kinase that contributes
to epithelial-to-mesenchymal transition and enhances cancer progression. Our previous …