Cubosomes: the next generation of smart lipid nanoparticles?

HMG Barriga, MN Holme… - Angewandte Chemie …, 2019 - Wiley Online Library
Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized
by a polymer based outer corona. Bicontinuous lipid cubic phases consist of a single lipid …

Non-lamellar lyotropic liquid crystalline lipid nanoparticles for the next generation of nanomedicine

J Zhai, C Fong, N Tran, CJ Drummond - ACS nano, 2019 - ACS Publications
Nonlamellar lyotropic liquid crystalline (LLC) lipid nanomaterials have emerged as a
promising class of advanced materials for the next generation of nanomedicine, comprising …

Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and In Situ Nucleic Acid Complexation

H Yu, A Angelova, B Angelov, B Dyett… - Angewandte …, 2023 - Wiley Online Library
Ionisable amino‐lipid is a key component in lipid nanoparticles (LNPs), which plays a crucial
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …

Inverse cubic and hexagonal mesophase evolution within ionizable lipid nanoparticles correlates with mRNA transfection in macrophages

H Yu, J Iscaro, B Dyett, Y Zhang, S Seibt… - Journal of the …, 2023 - ACS Publications
mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …

Paclitaxel-loaded self-assembled lipid nanoparticles as targeted drug delivery systems for the treatment of aggressive ovarian cancer

J Zhai, RB Luwor, N Ahmed, R Escalona… - … applied materials & …, 2018 - ACS Publications
Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective
treatments for advanced ovarian cancer. However, due to nonspecific targeting of the drug …

Curcumin- and Fish Oil-Loaded Spongosome and Cubosome Nanoparticles with Neuroprotective Potential against H2O2-Induced Oxidative Stress in Differentiated …

M Rakotoarisoa, B Angelov, VM Garamus… - ACS …, 2019 - ACS Publications
Many phytochemical antioxidant compounds, including curcumin (CU), are water-insoluble
and thus require delivery carriers in order to increase their bioavailability for in vivo …

Self‐assembled nanostructured lipid systems: is there a link between structure and cytotoxicity?

A Tan, L Hong, JD Du, BJ Boyd - Advanced Science, 2019 - Wiley Online Library
Self‐assembly of lipid‐based liquid crystalline (LLC) nanoparticles is a formulation art
arising from the hydrophilic–lipophilic qualities and the geometric packing of amphiphilic …

pH‐Dependent Lyotropic Liquid Crystalline Mesophase and Ionization Behavior of Phytantriol‐Based Ionizable Lipid Nanoparticles

H Yu, B Dyett, N Kirby, X Cai, ME Mohamad… - Small, 2024 - Wiley Online Library
Self‐assembled lipid nanoparticles (LNPs), serving as essential nanocarriers in recent
COVID‐19 mRNA vaccines, provide a stable and versatile platform for delivering a wide …

Effect of cholesterol on biomimetic membrane curvature and coronavirus fusion peptide encapsulation

I Milogrodzka, DT Nguyen Pham, GR Sama… - ACS …, 2023 - ACS Publications
Biomimetic cubic phases can be used for protein encapsulation in a variety of applications
such as biosensors and drug delivery. Cubic phases with a high concentration of cholesterol …

Characterization of lipid-based lyotropic liquid crystal and effects of guest molecules on its microstructure: a systematic review

X Wang, Y Zhang, S Gui, J Huang, J Cao, Z Li, Q Li… - AAPS …, 2018 - Springer
Liquid crystals (LCs) are conventionally divided into thermotropic or lyotropic, based on the
organization and sequence of the controlled molecular system. Lipid-based lyotropic liquid …