Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …

Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations
in human cancer. The majority of the mutations occur in the core domain which contains the …

Retinoids play an important role in development, differentiation, and homeostasis. The
discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated …

Zinc ions are key structural components of a large number of proteins. The binding of zinc
stabilizes the folded conformations of domains so that they may facilitate interactions …

Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

1. Glucocorticoids are widely used for the suppression of inflammation in chronic
inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease …