Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies

HJ Shields, A Traa, JM Van Raamsdonk - Frontiers in cell and …, 2021‏ - frontiersin.org
Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies

JS Bhatti, GK Bhatti, PH Reddy - … et Biophysica Acta (BBA)-Molecular Basis …, 2017‏ - Elsevier
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

N Couto, J Wood, J Barber - Free radical biology and medicine, 2016‏ - Elsevier
In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …

[HTML][HTML] Mammalian mitochondria and aging: an update

TES Kauppila, JHK Kauppila, NG Larsson - Cell metabolism, 2017‏ - cell.com
Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Neuronal cells rearrangement during aging and neurodegenerative disease: metabolism, oxidative stress and organelles dynamic

V Castelli, E Benedetti, A Antonosante… - Frontiers in molecular …, 2019‏ - frontiersin.org
Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Glutathione!

J Pizzorno - Integrative Medicine: A Clinician's Journal, 2014‏ - pmc.ncbi.nlm.nih.gov
My awareness of the importance of glutathione in health began with the brilliant commentary
on oceanic disease (IMCJ 7.1) by associate editor Sid Baker, MD. 1 Since then, as I have …

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

SR Kennedy, JJ Salk, MW Schmitt, LA Loeb - PLoS genetics, 2013‏ - journals.plos.org
Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage
and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations …

Why do we age?

TBL Kirkwood, SN Austad - Nature, 2000‏ - nature.com
The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into
the mechanisms underlying the complex cellular and molecular changes that contribute to …

Oxidative DNA damage and disease: induction, repair and significance

MD Evans, M Dizdaroglu, MS Cooke - Mutation Research/Reviews in …, 2004‏ - Elsevier
The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction

Y Mikhed, A Daiber, S Steven - International journal of molecular sciences, 2015‏ - mdpi.com
The prevalence of cardiovascular diseases is significantly increased in the older population.
Risk factors and predictors of future cardiovascular events such as hypertension …