Several epidemiologic and toxicological studies have commonly viewed ambient fine
particulate matter (PM2. 5), defined as particles having an aerodynamic diameter of less …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Background Regular, detailed reporting on population health by underlying cause of death
is fundamental for public health decision making. Cause-specific estimates of mortality and …

Background Estimates of demographic metrics are crucial to assess levels and trends of
population health outcomes. The profound impact of the COVID-19 pandemic on …

Background Cancer has been the leading cause of death since 2010 in China, with
increasing incidence, mortality, and burden. We aimed to assess national and subnational …

Importance Cancers are a leading cause of mortality, accounting for nearly 10 million annual
deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries' economic …

Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …

Background: We projected global trends in ischemic stroke from 2020 to 2030 according to
age, sex, and socio-demographic index (SDI) quintile. Methods: Estimated annual …

Abstract Background The triglyceride-glucose (TyG) index and triglyceride to high-density
lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin …

Hypertension affects more than one billion people worldwide. Here we identify 113 novel
loci, reporting a total of 2,103 independent genetic signals (P< 5× 10− 8) from the largest …