Several epidemiologic and toxicological studies have commonly viewed ambient fine
particulate matter (PM2. 5), defined as particles having an aerodynamic diameter of less …

Background Chronic obstructive pulmonary disease (COPD) is an increasingly important
cause of morbidity, disability, and mortality worldwide. We aimed to estimate global …

Background Regular, detailed reporting on population health by underlying cause of death
is fundamental for public health decision making. Cause-specific estimates of mortality and …

Background Estimates of demographic metrics are crucial to assess levels and trends of
population health outcomes. The profound impact of the COVID-19 pandemic on …

Importance Cancers are a leading cause of mortality, accounting for nearly 10 million annual
deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries' economic …

Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …

The sodium–glucose cotransporter 2 inhibitor empagliflozin reduces the risk of
cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

BackgroundRegularly updated data on stroke and its pathological types, including data on
their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are …

Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …