There is an epidemic of opioid use, abuse, and misuse in the United States, which results in
significant morbidity and mortality. It may be difficult to reduce perioperative opioid use given …

Abstract Purpose of Review Postoperative pain remains one of the most common
challenges following inpatient and outpatient surgeries. With our advances in modern …

The term 'adjuvant analgesics' was originally applied to drugs that were approved for
indications other than pain but were useful as coanalgesics during opioid therapy. During …

The treatment of acute pain requires special attention when focused on older adults, who
are usually defined as those age 65 years or older. Various physiologic changes occur with …

Purpose Pain is a frequent finding in surgical and trauma patients, and effective pain control
remains a common challenge in the hospital setting. Opioids have traditionally been the …

Abstract Purpose of Review Many surgical subspecialties have developed enhanced
recovery after surgery (ERAS) protocols that focus on multimodal analgesia to limit opioid …

In the context of the current US opioid crisis, there is renewed interest and heightened
relevance in the practice of multimodal analgesia for postoperative surgical patients. The …

Abstract Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-
nociceptive effects and thus may become a promising therapeutic strategy for neuropathic …

Purposes The postoperative analgesic effect of tizanidine has not yet been evaluated
sufficiently. The role of bilateral superficial cervical plexus block (BSCPB) for postoperative …

Background: We aimed to investigate the effect of preoperative administration of oral
tizanidine on postoperative pain intensity after bimaxillary orthognathic surgery. Methods: All …