NAMI-A and KP1019/1339, two iconic ruthenium anticancer drug candidates face-to-face: A case story in medicinal inorganic chemistry
NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
Metallodrugs in medicinal inorganic chemistry
KD Mjos, C Orvig - Chemical reviews, 2014 - ACS Publications
Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …
Thirty years of the drug candidate NAMI‐A and the myths in the field of ruthenium anticancer compounds: a personal perspective
E Alessio - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
Mixed quantum mechanical/molecular mechanical molecular dynamics simulations of biological systems in ground and electronically excited states
The quantum nature of electrons and nuclei is manifested in countless biological events
including the rearrangements of electrons in biochemical reactions, electron and proton …
including the rearrangements of electrons in biochemical reactions, electron and proton …
Metal-based anticancer chemotherapeutic agents
Highlights•Rational design of Pt IV prodrugs to reduce toxicity and resistance of clinical Pt II
drugs.•Conjugation of targeting or imaging agents to Pt IV centers.•Multinuclear Pt II …
drugs.•Conjugation of targeting or imaging agents to Pt IV centers.•Multinuclear Pt II …
Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
Challenges and opportunities in the development of organometallic anticancer drugs
This review provides an introduction into the fascinating area of organometallic anticancer
compounds. Although the subject dates back many years, it has witnessed considerable …
compounds. Although the subject dates back many years, it has witnessed considerable …
Bioactive luminescent transition‐metal complexes for biomedical applications
The serendipitous discovery of the anticancer drug cisplatin cemented medicinal inorganic
chemistry as an independent discipline in the 1960s. Luminescent metal complexes have …
chemistry as an independent discipline in the 1960s. Luminescent metal complexes have …
An overview of advancement of organoruthenium (II) complexes as prospective anticancer agents
The successful clinical translation of platinum drugs for cancer treatment has witnessed an
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …
Anticancer cyclometalated complexes of platinum group metals and gold
N Cutillas, GS Yellol, C de Haro, C Vicente… - Coordination chemistry …, 2013 - Elsevier
The clinical success of cisplatin and its derivatives has had an enormous impact on the
discovery of novel metal-based drugs. Extensive studies have focused on the interaction of …
discovery of novel metal-based drugs. Extensive studies have focused on the interaction of …