The evolution of iron chelators from a range of primordial siderophores and aromatic
heterocyclic ligands has lead to the formation of a new generation of potent and efficient iron …

Virtually all living cells possess an absolute re-Ž. quirement for iron Fe, and it has been
suggested that reactions catalyzed by Fe may have constituted a wx first step in the origin of …

Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron
overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as …

To develop the next-generation Pt drug with remarkable activity and low toxicity to maximally
inhibit tumor growth, we optimized a Pt (II) thiosemicarbazone compound (C4) with …

The chemical and biological effects of thiosemicarbazones have received considerable
interest from medicinal chemists for many years. This is attributed to, first, their wide …

Novel chemotherapeutics with marked and selective antitumor activity are essential to
develop, particularly those that can overcome resistance to established therapies. Iron (Fe) …

Iron (Fe) is an obligate requirement for life and it is well known that Fe depletion leads to
G1/S arrest and apoptosis. These facts, together with studies showing that Fe chelators can …

Siderophores are low molecular weight, high affinity iron chelating molecules that are
essential virulence factors in many Gram-negative bacterial pathogens. Whereas the …

The metal-chelating compound Dp44mT is a di-2-pyridylketone thiosemicarbazone (DpT)
which displays potent and selective antitumor activity. This compound is receiving …

Aroylhydrazone and thiosemicarbazone iron (Fe) chelators have potent antitumor activity.
The aim of the current study was to examine the antitumor effects and mechanisms of action …