Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

In the past 2 decades, major changes have occurred in the epidemiological and treatment
landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of …

Importance Patients with heart failure and preserved ejection fraction (HFpEF) are at high
risk of mortality, hospitalizations, and reduced functional capacity and quality of life …

The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Background The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in
patients with heart failure and reduced ejection fraction who had recently been hospitalized …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Background Riociguat, a member of a new class of compounds (soluble guanylate cyclase
stimulators), has been shown in previous clinical studies to be beneficial in the treatment of …

Background Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase 2
trial to be beneficial in the treatment of pulmonary arterial hypertension. Methods In this …

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Abstract Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …