Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Circadian (~ 24 hour) clocks have a fundamental role in regulating daily physiology. The
transcription factor BMAL1 is a principal driver of a molecular clock in mammals. Bmal1 …

A wide variety of liver functions are regulated daily by the liver circadian clock and via
systemic circadian control by other organs and cells within the gastrointestinal tract as well …

Almost all living organisms have evolved autoregulatory transcriptional‐translational
feedback loops that produce oscillations with a period of approximately 24‐h. These …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

REV-ERBα (NR1D1) is a circadian clock component that functions as a transcriptional
repressor. Due to its role in direct modulation of metabolic genes, REV-ERBα is regarded as …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven
inflammation of adipose tissue. Whether anti-inflammatory glucocorticoids (GCs) at …

The circadian clock controls several aspects of mammalian physiology and orchestrates the
daily oscillations of biological processes and behavior. Our circadian rhythms are driven by …