Apelin/APJ system: an emerging therapeutic target for neurological diseases

A Li, Q Zhao, L Chen, Z Li - Molecular Biology Reports, 2023 - Springer
Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively
expressed in various systems, especially the nervous system. This article reviews the role of …

[HTML][HTML] Aging Skeletal Muscles: What Are the Mechanisms of Age-Related Loss of Strength and Muscle Mass, and Can We Impede Its Development and Progression …

T Gustafsson, B Ulfhake - International Journal of Molecular Sciences, 2024 - mdpi.com
As we age, we lose muscle strength and power, a condition commonly referred to as
sarcopenia (ICD-10-CM code (M62. 84)). The prevalence of sarcopenia is about 5–10% of …

[HTML][HTML] Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: imperative roles of AMPK/Akt/CREB …

AMA Mahmoud, EM Mantawy, SA Wahdan… - Biomedicine & …, 2023 - Elsevier
Cisplatin (CP) is a broad-spectrum antineoplastic agent used to treat many human cancers.
Nonetheless, most patients receiving CP suffer from cognitive deficits, a phenomenon …

Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus

S Saral, A Topçu, M Alkanat, T Mercantepe… - Journal of Chemical …, 2023 - Elsevier
Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin
has many side effects, including cognitive impairment. Agomelatine, a synthetic melatonin …

Adipokines as immune cell modulators in multiple sclerosis

M Rijnsburger, N Djuric, IA Mulder… - International journal of …, 2021 - mdpi.com
Multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central
nervous system (CNS), is a major clinical and societal problem, which has a tremendous …

Apelin-13 attenuates depressive-like behaviors induced by chronic unpredictable mild stress via activating AMPK/PGC-1α/FNDC5/BDNF pathway

S Hu, L He, B Chen, Y You - Peptides, 2022 - Elsevier
Chronic stress induces neuronal death and impairs hippocampal neurogenesis, thus
leading to cognitive deficits and depressive-like behaviors. Our previous studies found that …

[HTML][HTML] Nucleosides rich extract from Cordyceps cicadae alleviated cisplatin-induced neurotoxicity in rats: a behavioral, biochemical and histopathological study

N Liu, S Zhou, OJ Olatunji, Y Wu - Arabian Journal of Chemistry, 2022 - Elsevier
This work explored the protective effects of nucleosides rich extract from C. cicadae (CCNE)
against cisplatin-induced neurotoxicity. The rats were divided into four groups: normal …

A partial agonist of PPARγ prevents paclitaxel‐induced peripheral neuropathy in mice, by inhibiting neuroinflammation

L Benvenutti, FR Wolff, TP Corrêa… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a
common side effect of paclitaxel, affecting 30‐50% of patients. Increased survival and …

Behavioral and cognitive consequences of obesity in parents and offspring in female and male rats: Implications of neuroinflammation and neuromodulation

EA Demir, G Gulbol-Duran, M Urhan-Kucuk… - Molecular …, 2022 - Springer
Obesity is a rapidly growing public health concern that can create a family-wise burden. This
study was aimed to investigate behavioral, cognitive, neuroinflammatory, and …

Bee pollen increases hippocampal brain-derived neurotrophic factor and suppresses neuroinflammation in adult rats with chronic immobilization stress

Ö Saral, H Şahin, S Saral, M Alkanat, K Akyıldız… - Neuroscience …, 2022 - Elsevier
Chronic stress is a potential problem associated with anxiety, depression, and cognitive
dysfunction. Bee pollen, a powerful antioxidant, has many therapeutic effects. In this study …