Genetic and genomic studies have enhanced our understanding of complex
neurodegenerative diseases that exert a devastating impact on individuals and society. One …

Today, the average life expectancy in developed nations is over 80 years and climbing. And
yet, the quality of life during those additional years is often significantly diminished by the …

Psoriasis is a common inflammatory disorder of the skin and other organs. We have
determined that mutations in CARD14, encoding a nuclear factor of kappa light chain …

We executed a genome-wide association scan for age-related macular degeneration (AMD)
in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH (P< …

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …

Age-related macular degeneration (AMD) is the most common cause of irreversible vision
loss in the developed world and has a strong genetic predisposition. A locus at human …

Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause
of visual impairment in developed countries. Risk factors include environmental components …

Age-related macular degeneration (AMD) is a common, late-onset disease with seemingly
typical complexity: recurrence ratios for siblings of an affected individual are three-to sixfold …

On the basis of genomewide linkage studies of families affected with age-related
maculopathy (ARM), we previously identified a significant linkage peak on 10q26, which has …

Genetic variants at chromosomes 1q31-32 and 10q26 are strongly associated with
susceptibility to age-related macular degeneration (AMD), a common blinding disease of the …