DNA switches are ideally suited for numerous nanotechnological applications, and
increasing efforts are being directed toward their engineering. In this review, we discuss how …

Life is orchestrated by biomolecules interacting in complex networks of biological circuitry
with emerging function. Progress in different areas of chemistry has made the design of …

Nucleic acid detection methods based on CRISPR and isothermal amplification techniques
show great potential for point-of-care diagnostic applications. However, most current …

This work reports on fully integrated “sample‐in‐signal‐out” microfluidic paper‐based
analytical devices (μPADs) relying on bioluminescence resonance energy transfer (BRET) …

DNA‐based probes have gained significant attention as versatile tools for biochemical
analysis, benefiting from their programmability and biocompatibility. However, most existing …

The functioning of bioluminescent systems in most of the known marine organisms is based
on the oxidation reaction of the same substrate—coelenterazine (CTZ), catalyzed by …

Allostery enables proteins to interconvert different biochemical signals and form complex
metabolic and signaling networks. We hypothesize that circular permutation of proteins …

Nucleic acid biosensors, integrated with functional nucleic acids, have drawn extensive
attention for diverse biomedical applications. In particular, many nucleic acid probes have …

Bioluminescent sensor proteins have recently gained popularity in both basic research and
point-of-care diagnostics. Sensor proteins based on intramolecular complementation of split …

Expanding the scope of bioorthogonal reactivity requires access to new and mutually
compatible reagents. We report here that 1, 2, 4-triazines can be tuned to exhibit unique …