Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

Maintaining genome stability is essential to an organism's health and survival. Breakdown of
the mechanisms protecting the genome and the resulting genome instability are an …

Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin
enriched with the histone H3 variant CENP‐A, the epigenetic mark that identifies centromere …

The centromere is a specialized region on the chromosome that directs equal chromosome
segregation. Centromeres are usually not defined by DNA sequences alone. How …

Posttranslational modifications (PTMs) of histone proteins are important for various cellular
processes including regulation of gene expression and chromatin structure, DNA damage …

Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A.
Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) …

CRISPR-based active genetic elements, or gene-drives, copied via homology-directed
repair (HDR) in the germline, are transmitted to progeny at super-Mendelian frequencies …

Centromere protein A (CENP-A) is a histone H3 variant that defines centromeric chromatin
and is essential for centromere function. In most eukaryotes, CENP-A-containing chromatin …

During mitosis, many cellular structures are organized to segregate the replicated genome
to the daughter cells. Chromatin is condensed to shape a mitotic chromosome. A …

Centromere dysfunctions leading to numerical chromosome alterations are believed to be
closely related to human cancers. As a centromere-specific protein, centromere protein A …