Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …

The formation of oximes and hydrazones is employed in numerous scientific fields as a
simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as …

The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

This review covers reactions where iminium ions are likely to be active intermediates in the
catalytic cycle. The focus of the review is on synthetically useful protocols and smallmolecule …

Hydrogels are an important class of biomaterials with the unique property of high‐water
content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels …

Molecules containing carbon–nitrogen double bonds are prevalent in both chemical and
biological contexts. The foundations for our current understanding of carbon–nitrogen …

Antibody-drug conjugates (ADCs) allow selective targeting of cytotoxic drugs to cancer cells
presenting tumor-associated surface markers, thereby minimizing systemic toxicity …

Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …