Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or
WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and …

Mesenchymal cells are an essential cell type because of their role in tissue support, their
multilineage differentiation capacities and their potential clinical applications. They play a …

Proper lung function relies on the precise balance of specialized epithelial cells that
coordinate to maintain homeostasis. Herein, we describe essential roles for the …

Alveolar type II (ATII) cells are progenitors in alveoli and can repair the alveolar epithelium
after injury. They are intertwined with the microenvironment for alveolar epithelial cell …

Airway inflammation and remodelling are important pathophysiologic features in asthma and
other respiratory conditions. An intact epithelial cell layer is crucial to maintain lung …

The lungs are an immunologically unique environment; they are exposed to innumerable
pathogens and particulate matter daily. Appropriate clearance of pathogens and response to …

The transcriptional regulators YAP and TAZ are involved in numerous physiological
processes including organ development, growth, immunity and tissue regeneration. YAP …

The advancement of new therapies, including targeted therapies and immunotherapies, has
improved the survival of non-small-cell lung cancer (NSCLC) patients in the last decade …

Ventilation is dependent upon pulmonary alveoli lined by two major epithelial cell types,
alveolar type-1 (AT1) and 2 (AT2) cells. AT1 cells mediate gas exchange while AT2 cells …

Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and
have been historically challenging to isolate or maintain in cell culture. Here, we engineer a …