Proteus mirabilis, a Gram-negative rod-shaped bacterium most noted for its swarming
motility and urease activity, frequently causes catheter-associated urinary tract infections …

RcsB, a response regulator of the FixJ/NarL family, is at the center of a complex network of
regulatory inputs and outputs. Cell surface stress is sensed by an outer membrane …

Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense
and respond to changes in their environment. TCSs typically consist of two proteins that …

Bacteria thrive in virtually all environments. Like all other living organisms, bacteria may
encounter various types of stresses, to which cells need to adapt. In this chapter, we …

The Rcs phosphorelay system, a non-orthodox two-component regulatory system, integrates
environmental signals, regulates gene expression, and alters the physiological behavior of …

Millions of deaths a year across the globe are linked to antimicrobial resistant infections. The
need to develop new treatments and repurpose of existing antibiotics grows more pressing …

The overall role of the Rcs phosphorelay in Proteus mirabilis is largely unknown. Previous
work had demonstrated that the Rcs phosphorelay represses the flhDC operon and …

Swarming on rigid surfaces requires movement of cells as individuals and as a group of
cells. For the bacterium Proteus mirabilis, an individual cell can respond to a rigid surface by …

One of the most fascinating sights in nature is to witness certain insects, birds, and fish move
together in a very coordinated and precise fashion for food search, to avoid predation and …

Colonies of the opportunistic pathogen Proteus mirabilis can distinguish self from non-self:
in swarming colonies of two different strains, one strain excludes the other from the …