Data-driven modelling of neurodegenerative disease progression: thinking outside the black box
Data-driven disease progression models are an emerging set of computational tools that
reconstruct disease timelines for long-term chronic diseases, providing unique insights into …
reconstruct disease timelines for long-term chronic diseases, providing unique insights into …
The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder
KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Brain aging process is influenced by various lifestyle, environmental and genetic factors, as
well as by age-related and often coexisting pathologies. Magnetic resonance imaging and …
well as by age-related and often coexisting pathologies. Magnetic resonance imaging and …
Genomic loci influence patterns of structural covariance in the human brain
Normal and pathologic neurobiological processes influence brain morphology in
coordinated ways that give rise to patterns of structural covariance (PSC) across brain …
coordinated ways that give rise to patterns of structural covariance (PSC) across brain …
Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
The genetic architecture of biological age in nine human organ systems
Investigating the genetic underpinnings of human aging is essential for unraveling the
etiology of and develo** actionable therapies for chronic diseases. Here, we characterize …
etiology of and develo** actionable therapies for chronic diseases. Here, we characterize …
Real-world evidence on clinical outcomes of commonly used antidepressants in older adults initiating antidepressants for depression: a nationwide cohort study in …
Objective: The authors investigated the clinical outcomes of commonly used antidepressants
among older adults who initiated first-time antidepressants for depression by analyzing the 1 …
among older adults who initiated first-time antidepressants for depression by analyzing the 1 …
[HTML][HTML] Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases.
However, the AD mechanism has not yet been fully elucidated to date, hindering the …
However, the AD mechanism has not yet been fully elucidated to date, hindering the …
Current approaches in computational psychiatry for the data-driven identification of brain-based subtypes
The ability of our current psychiatric nosology to accurately delineate clinical populations
and inform effective treatment plans has reached a critical point with only moderately …
and inform effective treatment plans has reached a critical point with only moderately …
Biological subty** of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine
Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …