Fluorouracil (5-FU) is amongst the most commonly used antimetabolite chemotherapeutic
agents in recent decades. However, its low bioavailability, short half-life, rapid metabolism …

Conventional chemotherapeutic approaches in cancer therapy such as surgery,
chemotherapy, and radiotherapy have several disadvantages due to their nontargeted …

Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of
research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease …

This study developed the pH, and over-expressed nucleolin receptor responsive nano-drug
delivery system (nDDS) composed by bio-synthesized gold nanoparticles (Au NPs) …

Abstract Poly-ε-caprolactone (PCL) has been the subject of extensive research in the past
few years. It is widely explored in drug delivery, where the development of nanomedicines …

The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and
to ensure their efficient uptake. Recently a number of studies have focused on designing bio …

Background Evaluation of the combinatorial anticancer effects of curcumin/5-fluorouracil
loaded thiolated chitosan nanoparticles (CRC-TCS-NPs/5-FU-TCS-NPs) on colon cancer …

Fluorouracil (5-FU) is a broad spectrum cytotoxic agent being used in chemotherapy of
malignancies. However, 5-FU shows a number of limitations like short half-life, non-selective …

Cancer is a major health concern worldwide as conventional treatment modalities face
several limitations such as drug resistance, toxicity etc. To overcome such deficits …

Fluorouracil (5-FU), an antimetabolite drug, is extensively used in the treatment solid tumors.
However, its severe side effects limit its clinical benefits. To enhance 5-FU anticancer …