Genomic views of distant-acting enhancers

A Visel, EM Rubin, LA Pennacchio - Nature, 2009 - nature.com
In contrast to protein-coding sequences, the significance of variation in non-coding DNA in
human disease has been minimally explored. A great number of recent genome-wide …

A bioinformatician's guide to metagenomics

V Kunin, A Copeland, A Lapidus… - Microbiology and …, 2008 - Am Soc Microbiol
As random shotgun metagenomic projects proliferate and become the dominant source of
publicly available sequence data, procedures for the best practices in their execution and …

Enhancing grain-yield-related traits by CRISPR–Cas9 promoter editing of maize CLE genes

L Liu, J Gallagher, ED Arevalo, R Chen, T Skopelitis… - Nature Plants, 2021 - nature.com
Several yield-related traits selected during crop domestication and improvement, are
associated with increases in meristem size, which is controlled by CLE peptide signals in the …

IRscope: an online program to visualize the junction sites of chloroplast genomes

A Amiryousefi, J Hyvönen, P Poczai - Bioinformatics, 2018 - academic.oup.com
Motivation Genome plotting is performed using a wide range of visualizations tools each
with emphasis on a different informative dimension of the genome. These tools can provide …

[HTML][HTML] Engineering quantitative trait variation for crop improvement by genome editing

D Rodríguez-Leal, ZH Lemmon, J Man, ME Bartlett… - Cell, 2017 - cell.com
Major advances in crop yields are needed in the coming decades. However, plant breeding
is currently limited by incremental improvements in quantitative traits that often rely on …

Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates

W Wang, CK Hu, A Zeng, D Alegre, D Hu, K Gotting… - Science, 2020 - science.org
INTRODUCTION The ability to regenerate tissues lost to damage or disease is widely but
nonuniformly distributed in vertebrates. Some animals such as teleost fishes can regenerate …

[HTML][HTML] Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection

A Hendelman, S Zebell, D Rodriguez-Leal, N Dukler… - Cell, 2021 - cell.com
Divergence of gene function is a hallmark of evolution, but assessing functional divergence
over deep time is not trivial. The few alleles available for cross-species studies often fail to …

African lungfish genome sheds light on the vertebrate water-to-land transition

K Wang, J Wang, C Zhu, L Yang, Y Ren, J Ruan, G Fan… - Cell, 2021 - cell.com
Lungfishes are the closest extant relatives of tetrapods and preserve ancestral traits linked
with the water-to-land transition. However, their huge genome sizes have hindered …

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons

I Braasch, AR Gehrke, JJ Smith, K Kawasaki… - Nature …, 2016 - nature.com
To connect human biology to fish biomedical models, we sequenced the genome of spotted
gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome …

MycoCosm portal: gearing up for 1000 fungal genomes

IV Grigoriev, R Nikitin, S Haridas, A Kuo… - Nucleic acids …, 2014 - academic.oup.com
MycoCosm is a fungal genomics portal (http://jgi. doe. gov/fungi), developed by the US
Department of Energy Joint Genome Institute to support integration, analysis and …