Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Actin is a highly conserved and fundamental protein in eukaryotes and participates in a
broad spectrum of cellular functions. Cells maintain a conserved ratio of actin isoforms, with …

Humans express 15 formins that play crucial roles in actin-based processes, including
cytokinesis, cell motility and mechanotransduction,. However, the lack of structures bound to …

The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their
regulated turnover, which is fundamental to many cellular functions. The mechanisms …

Arp2/3 complex generates branched actin networks that drive fundamental processes such
as cell motility and cytokinesis. The complex comprises seven proteins, including actin …

Cells control actin assembly by regulating reactions at actin filament barbed ends. Formins
accelerate elongation, cap** protein (CP) arrests growth and twinfilin promotes …

Actin filament turnover involves subunits binding to and dissociating from the filament ends,
with the pointed end being the primary site of filament disassembly. Several molecules …

Branched actin filaments are found in many key cellular structures. Branches are nucleated
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …

The dynamic actin cytoskeleton contributes to many critical biological processes by
providing the structural support underlying the morphology of most cells, facilitating …

The Arp2/3 complex, which generates both branched but also linear actin filaments via
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …