From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

With computation models playing an ever increasing role in the advancement of science, it is
important that researchers understand what it means to model something; recognize the …

Just as in clay moulding or glass blowing, physically sculpting biological structures requires
the constituent material to locally flow like a fluid while maintaining overall mechanical …

Cell motion inside dense tissues governs many biological processes, including embryonic
development and cancer metastasis, and recent experiments suggest that these tissues …

From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of
close-packed collective systems—both inert and living—have the potential to jam. The …

Cell migration is important in many biological processes, including embryonic development,
cancer metastasis and wound healing. In these tissues, a cell's motion is often strongly …

Pathological morphological changes in tumor tissue enable collective cancer cell
unjamming, a cellular motility transition. However, fundamental questions remain: Is …

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …

Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

The physical state of embryonic tissues emerges from non-equilibrium, collective
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …