Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …

Objective To investigate the effectiveness and safety of surgery compared with non-surgical
treatment for sciatica. Design Systematic review and meta-analysis. Data sources Medline …

Background Percutaneous coronary intervention (PCI) is frequently performed to reduce the
symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in …

Sham interventions in randomized clinical trials (RCTs) of physical, psychological, and self-
management (PPS) therapies for pain are highly variable in design and believed to …

Background Systematic reviews are an important tool of evidence-based surgery. Surgical
systematic reviews and trials, however, require a special methodological approach. Purpose …

Bioadhesive performance can be compromised due to bleeding. Bleeding increases
mortality. Adhesives with hemostatic function are of great significance. A sustainable and …

Background Placebo or sham controls are the standard against which the benefits and
harms of many active interventions are measured. Whilst the components and the method of …

Importance Nonspecific effects, particularly placebo effects, are thought to contribute
significantly to the observed effect in surgical trials. Objective To estimate the proportion of …

Many questions regarding the clinical management of people experiencing pain and related
health policy decision-making may best be answered by pragmatic controlled trials. To …

Pain is the most common symptom in chronic pancreatitis (CP) with a major impact on
quality of life. Few validated questionnaires to assess pain in CP exist, and the lack of …